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The body has a certain tolerance level to itching. Once you pass a certain threshold level of histamines, your rash and itching will spread out of control.
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Itch: From mechanism to (novel) therapeutic approaches - ScienceDirect
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The emerging role of neuroimmune interactions in atopic dermatitis and itch - Fan - 2022 - The FEBS Journal - Wiley Online Library
All About Itching
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Identification of a bilirubin receptor that may mediate a
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