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Cognitive impairment and a build-up of abnormal proteins in the brain are better known tell-tale signs of Alzheimer's disease, but other clues may reveal its presence earlier in the piece. Among those is a reduced blood flow to the brain, and scientists from Cornell University believe they have now found an explanation for these blockages, raising new hopes for treatments that target one of the disease's potential root causes.
Cortical-blood vessel assembloids exhibit Alzheimer's disease phenotypes by activating glia after SARS-CoV-2 infection
New Study Shows Lower Cerebral Blood Flow Precedes Brain Tissue Loss in Early Phase of Alzheimer's Disease - InventUM
Frontiers Systemic inflammation, blood-brain barrier vulnerability and cognitive / non-cognitive symptoms in Alzheimer disease: Relevance to pathogenesis and therapy
Frontiers The Glymphatic System in Diabetes-Induced Dementia
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
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Cortical-blood vessel assembloids exhibit Alzheimer's disease phenotypes by activating glia after SARS-CoV-2 infection
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IU School of Medicine researchers awarded $30
Frontiers Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors